Antidiabetic effects of Brucea javanica seeds in type 2 diabetic rats

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Antidiabetic effects of Brucea javanica seeds in type 2 diabetic rats

BACKGROUND Brucea javanica (B. javanica) seeds, also known as "Melada pahit" in Indo-Malay region are traditionally used to treat diabetes. The objective of this study was to determine antidiabetic, antioxidant and anti-inflammatory effects of B. javanica seeds on nicotinamide (NA)-streptozotocin (STZ) induced type 2 diabetic (T2D) rats and to analyze its chemical composition that correlate wit...

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Evaluation of Antidiabetic and Antioxidant Properties of Brucea javanica Seed

The ethanol extract of B. javanica seed was fractionated with solvents of different polarities and tested for antioxidant activities by several assays including DPPH radical scavenging activity, ferric reducing antioxidant power (FRAP), ferrous ion chelating activity (FCA), and nitric oxide radical scavenging activity (NORSA) along with their polyphenolic contents. Antidiabetic activity was eva...

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Computation of In Vivo Antidiabetic Activity of Holarrhena Antidysenterica Seeds Extracts in Streptozotocin-Induced Diabetic Rats

Medicinal plants have curative properties due to the presence of various complex chemical compositions, which are found as secondary plant metabolites in one or more parts of the plant. The aim of this study was to compute the antidiabetic activity of Holarrhena antidysenterica   seeds extract in streptozotocin-induced diabetic rats. The experimental protocol designed as animals were divided i...

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Antidiabetic Effects of Hesperidin and Naringin in Type 2 Diabetic Rats

This study was designed to investigate the effect of hesperidin and naringin on serum glucose, blood glycosylated hemoglobin and serum insulin levels in high fat fed (HFD)/streptozotocin (STZ)-induced type 2 diabetic rats. In addition, the effect on serum lipid profile, adiponectin and resistin levels, cardiac function parameters and liver and muscle glycogen contents was assessed. Hesperidin a...

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Evaluation of Antidiabetic and Antihyperlipidemic Effects of Peganum harmala Seeds in Diabetic Rats

The present study was carried out to investigate the antidiabetic and antihyperlipidemic properties of hydroalcoholic extract of Peganum harmala in streptozotocin-induced diabetic male rats. In an experimental study, 64 normal Wistar albino male rats (200-230 g) were randomly divided into 8 groups. Control and diabetic rats were treated with normal saline and three different doses (30, 60, and ...

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ژورنال

عنوان ژورنال: BMC Complementary and Alternative Medicine

سال: 2017

ISSN: 1472-6882

DOI: 10.1186/s12906-017-1610-x